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Head of AI Governance

EngagementFull-Time / Executive Leadership
LocationRemote / Hybrid
ImpactCategory-Defining Strategic & Technical Role
Technical ScopeML Models, Generative AI, Copilots, AI Agents, RAG Architectures

The Pitch & Mission

AI is transforming clinical care and drug discovery at a staggering pace—from predictive ML models to Generative AI, Copilots, Autonomous Agents, and RAG architectures. But innovation is stalled because enterprise governance hasn't kept up.

As Head of AI Governance at Uptake, you won't be managing static compliance spreadsheets or filling out manual risk surveys. You will lead the operationalization of enterprise AI governance into software—embedding active controls, drift monitoring, and programmatic guardrails directly into production pipelines across premier health systems and global pharma leaders.

Why This Role Is Category-Defining

Beyond Predictive Models

Lead governance frameworks that cover the entire AI spectrum: traditional ML, LLMs, enterprise Copilots, RAG retrieval methods, and autonomous agent workflows.

Governance as Infrastructure

Turn risk, legal, and compliance policies into automated, platform-native controls, continuous audit trails, and real-time kill-switches.

C-Suite & Regulatory Gravitas

Sit across the table from health system Chief AI Officers, hospital CMIOs, and Pharma CDOs as the definitive expert on enterprise algorithmic risk.

Key Responsibilities

Operationalizing governance across the enterprise AI lifecycle.

Enterprise AI Lifecycle Leadership

  • Oversee end-to-end AI governance across intake, risk assessment, continuous monitoring, and decommissioning.
  • Establish scalable, repeatable governance controls for traditional ML, Generative AI, Copilots, and Agentic systems.
  • Embed human-in-the-loop controls, tool interaction guardrails, and automated action boundaries into live workflows.

Risk, Compliance & Programmatic Controls

  • Operationalize standards aligning with FDA SaMD, GxP (21 CFR Part 11), EU AI Act, HIPAA, and CHAI frameworks.
  • Design risk-based review processes tailored to use-case complexity, patient impact, and data sensitivity.
  • Partner with client Legal, Risk, Compliance, Security, and Data Protection teams to convert policy into code.

Cross-Functional Engineering Alignment

  • Act as the bridge between Data Science, AI Engineering, Legal, and Clinical/R&D leadership.
  • Align AI governance controls with enterprise data quality, stewardship, and data management frameworks.
  • Work directly with Uptake's CTO to translate regulatory shifts into native platform features and API capabilities.

Performance Monitoring & Industry Influence

  • Define, track, and report governance metrics: control coverage, model drift events, bias detection, and risk remediation.
  • Represent Uptake AI in national working groups, standards bodies, and executive forums.
  • Author authoritative point-of-view pieces on responsible AI adoption at scale.

Qualifications & Requirements

  • 10+ Years of Experience in AI/ML governance, technology risk management, data governance, or regulatory affairs within regulated environments.
  • Proven Success Governing Modern AI: Demonstrated experience implementing frameworks for predictive ML, Generative AI applications, Copilots, and Retrieval-Augmented Generation (RAG) systems.
  • Complete Lifecycle Mastery: Deep understanding of AI development, intake workflows, risk controls, continuous monitoring, and model decommissioning.
  • Regulatory Fluency: Expert-level understanding of FDA AI/ML guidance, GxP validation, EU AI Act, NIST AI RMF, and emerging healthcare standards (CHAI).
  • Cross-Functional Bridge Builder: Exceptional ability to translate complex legal, risk, and regulatory demands into practical software requirements for engineering and data science teams.
  • Executive Presence: Outstanding communication and facilitation skills, with a track record of influencing senior business, clinical, and technical leaders.

Ready to Shape the Future of AI Safety?

💡 We personally read every cover letter! Tell us how you would approach governing autonomous agents or RAG architectures in a high-stakes clinical or pharma environment.

To apply, please send your resume and a cover letter directly to:

contact@getuptake.ai